Title of article
Biarylpyrimidines: a new class of ligand for high-order DNA recognition
Author/Authors
Murphy، Peter M. نويسنده , , Phillips، Victoria A. نويسنده , , Jennings، Sharon A. نويسنده , , Garbett، Nichola C. نويسنده , , Chaires، Jonathan B. نويسنده , , Jenkins، Terence C. نويسنده , , Wheelhouse، Richard T. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
-115
From page
116
To page
0
Abstract
Biarylpyrimidines bearing -aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.
Keywords
Riemann zeta function , characterization of distributions , Brownian motion , Bessel process , Levy process , gamma process , Mellin transform , Meixner process
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Serial Year
2003
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Record number
69288
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