Title of article :
Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism
Author/Authors :
Yanagawa، Hiroshi نويسنده , , Ohta، Hiromichi نويسنده , , Ijima، Yoichiro نويسنده , , Matoishi، Kaori نويسنده , , Terao، Yosuke نويسنده , , Doi، Nobuhide نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The introduction of two mutations (G74C/C188S) based on the estimated reaction mechanism resulted in the inversion of enantioselectivity of arylmalonate decarboxylase, which catalyses the asymmetric decarboxylation of arylmethylmalonate to give optically active arylpropionate.
Keywords :
Aphthona czwalinae , Euphorbia esula , Spurgia esulae , Biological control , IPM , Aphthona flava , Invasive weeds , Endangered species , Aphthona nigriscutis , Leafy spurge flea beetles , Aphthona lacertosa
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
