Title of article :
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination
Author/Authors :
Nicholson، T. P. نويسنده , , Winfield، C. نويسنده , , Westcott، J. نويسنده , , Crosby، J. نويسنده , , Simpson، T. J. نويسنده , , Cox، R. J. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
The minimal actinorhodin polyketide synthase bearing two point mutations (KS(beta) Q161A, ACP C17S) was chemically modified to carry novel C4 to C8 starter units on the ACP: on incubation with an excess of malonyl CoA new 16-carbon polyketides are made, supporting a measuring mechanism.
Keywords :
second order Dehn function , combing , asynchronously automatic group
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
