Unprecedented asymmetric induction through configurationally stable lithium N-((alpha)-methylbenzyl) phosphinamides. A new entry to enantiomerically pure (gamma)-aminophosphinic acids and esters

The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral (gamma)-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown.