Author/Authors :
Tanaka، Ryoji نويسنده , , Katsu، Takashi نويسنده , , Kawai، Masao نويسنده , , Yamamura، Hatsuo نويسنده , , Yasuda، Keiko نويسنده , , Narita، Shizuto نويسنده , , Umemoto، Hiroshi نويسنده , , Ando، Setsuko نويسنده ,
Abstract :
Novel (2S,4R)- and (2S,4S)-4-aminoproline residue-containing analogs of the cyclic decapeptide antibiotic gramicidin S were synthesized, which exhibited marked permeabilizing activity on the outer membrane of gram-negative bacteria.
