Title of article :
Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy
Author/Authors :
Bond، Andrew D. نويسنده , , Holmes، Andrew B. نويسنده , , Chiang، Gary C. H. نويسنده , , Ayscough، Andrew نويسنده , , Pain، Gilles نويسنده , , Ducki، Sylvie نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The enantioselective synthesis of a simplified eleutherobin analogue 7 by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin 5 is described; the analogue 7 and an advanced intermediate 15 revealed microtubule stabilising properties in the micromolar range.
Keywords :
Aminolysis of epoxides , Synthesis of (beta)-amino alcohols , Ti-MCM-41 , Titanosilicate molecular sieves
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
