Title of article
Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy
Author/Authors
Bond، Andrew D. نويسنده , , Holmes، Andrew B. نويسنده , , Chiang، Gary C. H. نويسنده , , Ayscough، Andrew نويسنده , , Pain، Gilles نويسنده , , Ducki، Sylvie نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-185
From page
186
To page
0
Abstract
The enantioselective synthesis of a simplified eleutherobin analogue 7 by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin 5 is described; the analogue 7 and an advanced intermediate 15 revealed microtubule stabilising properties in the micromolar range.
Keywords
Aminolysis of epoxides , Synthesis of (beta)-amino alcohols , Ti-MCM-41 , Titanosilicate molecular sieves
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Serial Year
2005
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Record number
70428
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