Entropy-controlled supramolecular photochirogenesis: enantiodifferentiating Z-E photoisomerization of cyclooctene included and sensitized by permethylated 6-O-benzoyl--cyclodextrin

In contrast to the photosensitization with a non-methylated analogue, supramolecular photochirogenesis with a novel permethylated mono(6-O-benzoyl)-(beta) -cyclodextrin exhibited a critical dependence of the productʹs enantiomeric excess upon temperature, and possessed a large differential entropy of activation (-11 J K^-1 mol^-1) for which the flexible host skeleton is likely to be responsible.