A step-by-step algorithm for combining diagnostic tests

Combining data of several tests or markers for the classification of patients according to their health status for assigning better treatments is a major issue in the study of diseases such as cancer. In order to tackle this problem, several approaches have been proposed in the literature. In this paper, a step-by-step algorithm for estimating the parameters of a linear classifier that combines several measures is considered. The optimization criterion is to maximize the area under the receiver operating characteristic curve. The algorithm is applied to different simulated data sets and its performance is evaluated. Finally, the method is illustrated with a prostate cancer staging database.