A Novel Approach to Furopyrimidinones Using Dry Media

An environmentally benign approach to the synthesis of furopyrimidin-4(3H)-one under microwave irradiation (MWI) using an inorganic solid support for catalytic activity as well as an energy-transfer medium is described. The reaction time can be decreased from hours to minutes along with a yield enhancement. In addition, the differential activity of various solid supports was studied for a reaction which enables one to accomplish the one-pot synthesis of the required product via the 2aminofuran-3-carbonitrile intermediate.