Catalytic Friedel-Crafts Acylation of Alkoxybenzenes Mediated by Aluminum Hydrogensulfate in Solution and SolventFree Conditions

Friedel-Crafts acylation of alkoxybenzenes was achieved efficiently by a reaction with aliphatic acid anhydrides in the presence of catalytic amounts of aluminum hydrogensulfate, Al(HSO4)3, in nitromethane and under solvent-free conditions. Alkylbenzenes and aryl halides, as well as aromatic anhydrides, remained intact under these conditions