• Title of article

    Nonparametric estimation in nonlinear mixed effects models

  • Author/Authors

    Lai، Tze Leung نويسنده , , Shih، Mei-Chiung نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    0
  • From page
    1
  • To page
    0
  • Abstract
    A nonparametric approach is developed herein to estimate parameters in nonlinear mixed effects models. Asymptotic properties of the nonparametric maximum likelihood estimators and associated computational algorithms are provided. Empirical Bayes estimators of functionals of the random effects are also developed. Applications to population pharmacokinetics are given.
  • Journal title
    Biometrika
  • Serial Year
    2002
  • Journal title
    Biometrika
  • Record number

    71706

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=71706