Title of article
Nonparametric estimation in nonlinear mixed effects models
Author/Authors
Lai، Tze Leung نويسنده , , Shih، Mei-Chiung نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
0
From page
1
To page
0
Abstract
A nonparametric approach is developed herein to estimate parameters in nonlinear mixed effects models.Asymptotic properties of the nonparametric maximum likelihood estimators and associated computational algorithms are provided. Empirical Bayes estimators of functionals of the random effects are also developed. Applications to population pharmacokinetics are given
Keywords
Information matrix , Quantitative trait locus , maximum likelihood , Mixture label , Nuisance parameter
Journal title
Biometrika
Serial Year
2002
Journal title
Biometrika
Record number
71763
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