Thermodynamics of partitioning of a series of chlorobenzenes to fish storage lipids, in comparison to partitioning to phospholipids

Lipid/water partition coefficients for storage lipids from fish (Kd,sl) were determined for a series of chlorobenzenes at three different temperatures. Kd,sl values were higher than lipid/water partition coefficients for phospholipids that were measured previously for the same compounds. Based on results of the present study and studies reported in the literature, it is concluded that fish lipids cannot be considered as a uniform compartment, the distinct properties of the various lipids result in different lipid/water partition coefficients. The partitioning of chlorobenzenes between storage lipid and water is enthalpy-driven. The entropy of the transfer from water to lipids is unfavourable for the tested compounds.