Title of article
Skin biopsy as a nondestructive tool for the toxicological assessment of endangered populations of pinnipeds: Preliminary results on mixed function oxidase in Otaria flavescens
Author/Authors
M. C. Fossi، نويسنده , , C. Savelli، نويسنده , , L. Marsili، نويسنده , , S. Casini، نويسنده , , B. Jimenez، نويسنده , , M. Junin، نويسنده , , H. Castello، نويسنده , , J. A. Lorenzani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
13
From page
1623
To page
1635
Abstract
The aim of this study was to develop and validate a method for assessing the toxicological risk of endangered populations of pinnipeds based on a nondestructive biological tool, the skin biopsy specimen. Skin biopsies can be obtained from pinnipeds by anaesthetising the animals and taking a small amount of skin in the anterior flipper area, or by shooting a biopsy dart with a crossbow. Skin biopsy material is suitable for a wide range of chemical and biomarker analysis. Organochlorines and polycyclic aromatic hydrocarbons can be analysed in subcutaneous fat and MFO activity (BPMO), Cyt.P450 isoforms, and DNA damage can be detected in epidermis.
Keywords
Pinnipeds , Skin biopsy , Nondestructive biomarkers , OCS , PAHs.
Journal title
Chemosphere
Serial Year
1997
Journal title
Chemosphere
Record number
723305
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