Effect of Clofibrate, a Peroxisome Proliferator, in Sea Bass (Dicentrarchus labrax), a Marine Fish

The effects of 35 or 70 mg/kg clofibrate on some peroxisomal, mitochondrial, and microsomal enzymes (markers of peroxisome proliferation) in liver, gill, and kidney of sea bass following 2 weeks i.p. treatment have been studied. Induction of lauric acid hydroxylase, UDP-glucuronyl transferase, palmitoyl-CoA oxidase, carnitine-palmitoyl-transferase,p-nitrophenylacetate hydrolase, and benzaldehyde and propionaldehyde dehydrogenase activities was not observed in any case. The clofibrate administration at the dose of 70 mg/kg induced in the liver the glutathioneS-tranferase and reduced epoxide hydrolase activities. These results demonstrate that a marine fish species, such as sea bass, is rafractary to peroxisome proliferation