Insect oostatic peptide: absence of effect on mice ovaries

An analogue of insect oostatic peptide, the pentapeptide H–Tyr–Asp–Pro–Ala–Pro–OH (H–YDPAP–OH), was administered to female mice and its effects on reproduction and development of the ovaries were studied. Up to 0.5 mg of the peptide per mice (25 g b.w.) injected intraperitoneally did not change the rate of pregnancy, number of offsprings and histological findings in ovaries and uterus in comparison to saline treated controls.