Acute aquatic toxicities of four musk xylene derivatives on Daphnia magna

Musk xylene derivatives were obtained by hydration of the parent compound. These materials were assayed for acute toxicity on Daphnia magna. In contrast to the parent compound all these reduction products showed acute toxicities below their water solubility. The para-amino-dinitro-musk xylene was highly toxic (EC50=0.00025 mg L−1). Ortho- and ortho-para and triamino-musk-xylene were less toxic and showed EC50-values of 1.07, 23.3, 58.8 mg L−1 respectively. A 1:1:1:1 mixture of all derivatives, each in a concentration corresponding to of EC50, exhibited a strong concentration-additivity relationship.