Acute toxicity of 4-amino musk xylene to Daphnia magna in laboratory water and natural water

A derivative of musk xylene, 4-amino musk xylene, was tested for acute toxicity to Daphnia magna in laboratory water (hard water) and natural water (soft water). Tests with both water types were conducted using standard lighting and in continuous darkness. The 48-h EC50 ranged from 370 to 510 μg/l. These results are consistent with QSAR predictions and with previous results for 2-amino musk xylene, but inconsistent with a previous report for 4-amino musk xylene. The acute toxicity concentration for D. magna is approximately four orders of magnitude greater than concentrations of 4-amino musk xylene measured in surface waters and treated sewage.