• Title of article

    Consistency of estimators of the population-scaled recombination rate

  • Author/Authors

    Paul Fearnhead، نويسنده ,

  • Issue Information
    دوماهنامه با شماره پیاپی سال 2003
  • Pages
    13
  • From page
    67
  • To page
    79
  • Abstract
    We consider (approximate) likelihood methods for estimating the population-scaled recombination rate from population genetic data. We show that the dependence between the data from two regions of a chromosome decays inversely with the amount of recombination between the two regions. We use this result to show that the maximum likelihood estimator (mle) for the recombination rate, based on the composite likelihood of Fearnhead and Donnelly, is consistent. We also consider inference based on the pairwise likelihood of Hudson. We consider two approximations to this likelihood, and prove that the mle based on one of these approximations is consistent, while the mle based on the other approximation (which is used by McVean, Awadalla and Fearnhead) is not.
  • Keywords
    Asymptotics , Composite likelihood , Maximum likelihood estimators , Pairwise likelihood , recombination rate
  • Journal title
    Theoretical Population Biology
  • Serial Year
    2003
  • Journal title
    Theoretical Population Biology
  • Record number

    773731