A case presentation of Sweetʹs syndrome and discussion of life-threatening dermatoses

Sweet first described acute febrile neutrophilic dermatosis in 1964. Since then, more than 425 cases of this typically benign, steroid-responsive disease have been recorded. Although often associated with myelodysplastic syndromes or hematologic malignancies, Sweetʹs syndrome has also been related to pregnancy, autoimmune disorders, and many drug therapies. Although it is not typically an acutely life-threatening illness, there is a potential for significant pulmonary involvement and respiratory compromise. Additionally, emergency physicians should be aware of this unusual disease and its frequent association with systemic illnesses. We report the first case of Sweetʹs syndrome in the emergency medicine literature and present a review and discussion of several common life-threatening dermatoses.