Combined oral and vaginal treatment of severe vulvovaginitis during childhood

Study Objective To evaluate the efficacy and safety of combined oral and vaginal administration of antibiotics. Design Treatment and follow-up examination of 54 cases of severe vulvovaginitis. Setting Division of Pediatric and Adolescent Gynecology, Second Department of Obstetrics and Gynecology, University of Athens, Greece. Participants Girls aged 1–10 years seen at the clinic of the above-listed institution. Interventions Vaginal application of antibiotics. Main Outcome Measures Vaginal culture and vaginoscopy. Results Treatment achieved microbial eradication in 51 of 54 patients (94%). In most patients, relief of syptoms was achieved after 2–3 days. No adverse effects were reported. Conclusions Treatment was highly effective and simple to administer, and no complications were observed. A further advantage of this approach is the shorter duration of treatment.