Title of article
Death and the retrovirus
Author/Authors
Jean-Pierre Vartanian، نويسنده , , Peter Sommer، نويسنده , , Simon Wain-Hobson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
409
To page
413
Abstract
A flurry of new papers has shown that HIV reverse transcription is vulnerable to G→A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.
Journal title
Trends in Molecular Medicine
Serial Year
2003
Journal title
Trends in Molecular Medicine
Record number
784142
Link To Document