Title of article :
BMP7 signaling in renal development and disease
Author/Authors :
Sanjeevkumar R. Patel، نويسنده , , Gregory R. Dressler، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
7
From page :
512
To page :
518
Abstract :
Fibrosis, and in particular tubulointerstitial fibrosis, is a common feature of almost all chronic renal diseases. Over the past several years, significant progress has been made in defining the underlying mechanisms of tubulointerstitial fibrosis. In a variety of mouse models, expression of transforming growth factor-β is a primary causative factor which leads to increased numbers of myofibroblasts, collagen deposition and loss of tubular epithelia. More recently, another member of the transforming growth factor-β superfamily, BMP7, was shown to counteract transforming growth factor-β-mediated fibrosis. The activities of these secreted factors are regulated, in part, by extracellular ligand binding proteins which can enhance or suppress receptor ligand interactions.
Journal title :
Trends in Molecular Medicine
Serial Year :
2005
Journal title :
Trends in Molecular Medicine
Record number :
784363
Link To Document :
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