Title of article
Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate
Author/Authors
Vera Gouvea، نويسنده , , Norma Snellings، نويسنده , , Michael J. Popek، نويسنده , , Charles F. Longer، نويسنده , , Bruce L. Innis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
21
To page
26
Abstract
The complete nucleotide sequence of the Nepali strain TK15/92 of hepatitis E (HEV) was determined. It showed the highest sequence homology with the Burmese B1 strain, but closer evolutionary relatedness to the Indian strains. Difficulties in reverse-transcribing and amplifying the hypervariable region in ORF1 suggested that strong secondary structures might be intrinsically responsible for the high mutational rate observed in this region of the HEV genome.
Keywords
phylogeny , Hypervariable region , Hepatitis E , HEY , Complete HEY sequence
Journal title
Virus Research
Serial Year
1998
Journal title
Virus Research
Record number
785144
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