Title of article
Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus
Author/Authors
Ranjit Ray، نويسنده , , Daniel F. Hoft، نويسنده , , Keith Meyer، نويسنده , , Robin Brown، نويسنده , , L. Martin Lagging، نويسنده , , Robert B. Belshe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
147
To page
154
Abstract
The secretory glycoprotein (Gs) of respiratory syncytial virus (RSV) was enriched and investigated for its effects on T cells specific for RSV and unrelated antigens. Gs exhibited a dose dependent suppression of lymphoproliferative responses in peripheral blood mononuclear cells (PBMCs), specific for mycobacterial lysates or tetanus toxoid. However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the overall development of RSV specific immunity.
Keywords
respiratory syncytial virus , Secreted glycoproteins , Lymphoproliferative responses
Journal title
Virus Research
Serial Year
2001
Journal title
Virus Research
Record number
785447
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