Title of article :
Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro
Author/Authors :
Eliana G. Acosta، نويسنده , , Andrea C. Bruttomesso، نويسنده , , Juan A. Bisceglia، نويسنده , , M?nica B. Wachsman، نويسنده , , Lydia R. Galagovsky، نويسنده , , Viviana Castilla، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
10
From page :
203
To page :
212
Abstract :
In the present paper the in vitro antiviral activity of dehydroepiandrosterone (DHEA), epiandrosterone (EA) and 16 synthetic derivatives against Junin virus (JUNV) replication in Vero cells was studied. DHEA and EA caused a selective inhibition of the replication of JUNV and other members of the Arenaviridae family such as Pichinde virus and Tacaribe virus. The compounds were not virucidal to cell-free JUNV. The impairment of viral replication was not due to an inhibitory effect of the steroids on virus adsorption or internalization. An inhibitory effect of the compounds on JUNV protein synthesis and both intracellular and extracellular virus production was demonstrated. A partial inhibitory action on cell surface expression of JUNV glycoprotein G1 was also detected on DHEA- and EA-treated cultures. Like DHEA and EA, three compounds obtained from EA by chemical synthesis showed selectivity indexes higher than ribavirin, the only antiviral compound that has shown partial efficacy against arenavirus infections.
Keywords :
ArenavirusJunin virusSteroidDehydroepiandrosteroneDHEAAntiviral activity
Journal title :
Virus Research
Serial Year :
2008
Journal title :
Virus Research
Record number :
786845
Link To Document :
بازگشت