Author/Authors :
Yuan-Pin Huang، نويسنده , , Tsuey-Li Lin، نويسنده , , Chuan-Yi Kuo، نويسنده , , Miao-Wen Lin، نويسنده , , Ching-Yuan Yao، نويسنده , , Hui-Wen Liao، نويسنده , , Li-Ching Hsu، نويسنده , , Chen-Fu Yang، نويسنده , , Jyh-Yuan Yang، نويسنده , , Pei-Jer Chen، نويسنده , , Ho-Sheng Wu، نويسنده ,
Abstract :
Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006–2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B; however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan.
