Author/Authors :
Abdel Azim، Alaa Mohammad نويسنده Department of toxic and narcotic drug forensic medicine, Cairo, Egypt , , El-Ashmoony، Manal نويسنده Department of pharmaceutics, faculty of pharmacy, Cairo university, Cairo, Egypt , , Swealem، Abdel Moneim نويسنده Department of Pharmaceutics, National Organization for Drug Control and Research, Cairo, Egypt , , shoukry، Ragia Ali نويسنده Department of pharmaceutics, faculty of pharmacy, Cairo university, Cairo, Egypt ,
Abstract :
The purpose was to develop transdermal delivery systems (TDS) of Glucosamine Sulphate using Pluronic F-127 (PF-127) and mucoadhesive polymer sodium carboxymethylcellulose (Na CMC) in order to optimize its release profile, and the clinical performance. Glucosamine (G) is known to be formulated in an oral dosage form, but it suffers from hepatic metabolism which greatly affects its bioavailability, in addition to its side effects on the gastrointestinal tract (GIT). Gel formulae were subjected to rheological studies, in-vitro release, and effect of 1% dimetylsulphoxide (DMSO) on rat skin permeation. Higuchi diffusion model was the best fitted model for the release results. PF127 and Na CMC gels showed high permeation results, and 25% PF-127 gel showed no skin irritation or histological change of skin layers. The results obtained suggest the feasibility of designing a successful TDS providing constant (G) input and overcoming the disadvantages of oral administration.
