Title of article
Synthesis of conformationally restricted substance P antagonists
Author/Authors
Harry R. Howard، نويسنده , , Kevin D. Shenk، نويسنده , , Karen C. Coffman، نويسنده , , Dianne K. Bryce، نويسنده , , Rosemary T. Crawford، نويسنده , , Stafford A. McLean، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
111
To page
114
Abstract
Reaction of CP-99,994 (1) with benzyl chloromethyl ether under basic conditions produced the novel 1,6-diazabicyclo[3.2.1]octane system in good yield; analogs containing this nucleus display high binding affinity for substance P receptors. The ethylene homologue of 1a, diamine 7, shows enhanced inhibitory activity and may more closely approximate the binding conformation of 1a at the NK1 receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787289
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