Title of article
Non-peptidic inhibitors of neutral endopeptidase 24.11 2. Design and pharmacology of orally active phosphonate prodrugs
Author/Authors
Stéphane De Lombaer، نويسنده , , Louis Blanchard، نويسنده , , Carol Berry، نويسنده , , Rajendra D. Ghai، نويسنده , , Angelo J. Trapani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
151
To page
154
Abstract
Prodrugs of 1 (CGS 26303), a novel non-peptidic neutral endopeptidase (NEP 24.11) inhibitor, have been designed. In particular, the diphenylphosphonate 6 (CGS 26393) was found to be a potent, orally bioavailable and long-acting NEP inhibitor. Accordingly, 6 protected atrial natriuretic peptide from enzymatic degradation and displayed a significant antihypertensive activity in the DOCA-salt rat.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787297
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