Title of article
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole
Author/Authors
Richard G. Wilde، نويسنده , , Jeffrey T. Billheimer، نويسنده , , Sandra J. Germain، نويسنده , , Peter J. Gillies، نويسنده , , C. Anne Higley، نويسنده , , Hollis S. Kezar III، نويسنده , , Thomas P. Maduskuie، نويسنده , , Edward S. Shimshick، نويسنده , , Ruth R. Wexler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
167
To page
172
Abstract
A series of compounds bearing heterocyclic substituents were prepared, and evaluated for inhibition of the ACAT enzyme. The heterocyclic groups were compared in terms of in vitro potency against their diarylimidazole analogues. Data for the purposes of QSAR were also collected. Our goal is a systemic ACAT inhibitor, which would be a potential antihypercholesterolemic and antiatherosclerotic agent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787301
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