Myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3,4-trisphosphorothioate: New synthetic Ca2+-mobilising partial agonists at the inositol 1,4,5-trisphosphate receptor

Syntheses of myo-inositol 1,4,6-trisphosphorothioate and 1,3,4-trisphosphorothioate from myo-inositol are described; these trisphosphorothioates, derived from structure-activity considerations of myo-inositol 1,3,4,6-tetrakisphosphate, are low intrinsic activity partial agonists at the platelet Ins(1,4,5)P3 receptor.