Title of article
Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity
Author/Authors
Luzviminda V. Tinao-Wooldridge، نويسنده , , Bonnie C. H. Hsiang، نويسنده , , Tammy N. Latifi، نويسنده , , James A. Ferrendelli، نويسنده , , Douglas F. Covey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
265
To page
270
Abstract
4,7,7-Trimethyl-6,8-dioxabicyclo[3.2.1]octan-2-one was found to be an effective anticonvulsant (ED50 = 131 mg/kg) against pentylenetetrazole-induced seizures in mice. Enantioselectively was observed in the actions of the (+)- and (−)-enantiomers as anticonvulsants and as displacers of [35S]-TPBS, a ligand for the picrotoxin site on GABAA receptors. The (−)-enantiomer was slightly more potent in both biological assays.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787321
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