Title of article :
Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 13. Design, synthesis and biological evaluation of tetrazole anilides as potent inhibitors of ACAT in vitro and hypocholesterolemic agents in vivo
Author/Authors :
Patrick M. OʹBrien، نويسنده , , Drago R. Sliskovic، نويسنده , , Adele Bernabei، نويسنده , , Timothy Hurley، نويسنده , , Maureen K. Anderson، نويسنده , , Richard F. Bousley، نويسنده , , Brian R. Krause، نويسنده , , Richard L. Stanfield، نويسنده ,
Abstract :
The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)-8b, stereoselectively inhibits ACAT in vitro and possesses superior efficacy in vivo compared to (−)-8b or the recemic mixture (±)-8b.
