Author/Authors :
Mark P. Wentland، نويسنده , , Suzanne C. Aldous، نويسنده , , Monte D. Gruett، نويسنده , , Robert B. Perni، نويسنده , , Ronald G. Powles، نويسنده , , Deborah W. Danz، نويسنده , , Kristina M. Klingbeil، نويسنده , , A. Danielle Peverly، نويسنده , , Ronald G. Robinson، نويسنده , , Thomas H. Corbett، نويسنده , , James B. Rake، نويسنده , , Susan A. Coughlin، نويسنده ,
Abstract :
Mammalian topoisomerase II inhibition activity has been identified in a series of novel pyrazoloquinoline derivatives; potency for two analogues containing cyclohexyl groups at the 2-position was comparable to the reference agents, mAMSA and VP-16. In several instances, topo II inhibition translated to a high level of in vitro cytotoxicity and murine antitumor activity.
