Title of article
Formation of nitrogen oxides including NO from oxidative cleavage of C=N(OH) bonds: A general cytochrome P450-dependent reaction.
Author/Authors
Anne Jousserandot، نويسنده , , Jean-Luc Boucher، نويسنده , , Carole Desseaux، نويسنده , , Marcel Delaforge، نويسنده , , Daniel Mansuy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
423
To page
426
Abstract
Several compounds such as aldoximes, ketoximes, amidoximes and guanidoximes were oxidized by liver microsomes from dexamethasone-treated rats with formation of nitrogen oxides such as NO2−, NO3− and NO. The oxidative cleavage of their C=N(OH) bond appears as a general P450 3A-catalyzed reaction, which is particularly efficient in the case of N,N′-disubstituted guanidoximes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787347
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