Title of article :
The asymmetric synthesis of both enantiomers of eliprodil
Author/Authors :
Romano Di Fabio، نويسنده , , Claudio Pietra، نويسنده , , Russell J. Thomas، نويسنده , , Luigi Ziviani، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Abstract :
The asymmetric synthesis of both enantiomers of the racemic NMDA antagonist eliprodil was accomplished in a novel application of Sharplessʹ asymmetric dihydroxylation (AD) methodology. A difference in neuroprotective activity was noted for the enantiomers in an in vivo model of rat focal cerebral ischemia.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
