Title of article
The asymmetric synthesis of both enantiomers of eliprodil
Author/Authors
Romano Di Fabio، نويسنده , , Claudio Pietra، نويسنده , , Russell J. Thomas، نويسنده , , Luigi Ziviani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
551
To page
554
Abstract
The asymmetric synthesis of both enantiomers of the racemic NMDA antagonist eliprodil was accomplished in a novel application of Sharplessʹ asymmetric dihydroxylation (AD) methodology. A difference in neuroprotective activity was noted for the enantiomers in an in vivo model of rat focal cerebral ischemia.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787371
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