Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic
Author/Authors :
M. Napoletano، نويسنده , , Bella D. Delia، نويسنده , , C. Fraire، نويسنده , , G. Grancini، نويسنده , , C. Masotto، نويسنده , , S. Ricciardi، نويسنده , , C. Zambon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
4
From page :
589
To page :
592
Abstract :
A stereoselective synthesis of 1 was devised in order to obtain all 12 possible isomers. The pharmacological data clearly show a highly stereochemical requirement for the affinity and selectivity towards the μ-receptor and the related analgesic activity.
