Design and synthesis of an antitumor prodrug released by the reaction with sulfhydryl compounds

The design and synthesis of carbamate-daunomycin prodrug 11 that can release free daunomycin by the reaction with sulfhydryl compounds is described. The compound 11 is more sensitive to adriamycinresistant L1210 cell line than free daunomycin with relative resistance of 3.7 and 9.2, respectively.