Title of article :
1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel
Author/Authors :
Sander G. Mills، نويسنده , , Malcolm MacCoss، نويسنده , , Margaret A. Cascieri، نويسنده , , Sharon Sadowski، نويسنده , , Smita Patel، نويسنده , , Kerry L. Chapman، نويسنده , , Peter H. Hutson، نويسنده ,
Abstract :
A series of 1,2,4-triacylpiperidines are shown to be potent antagonists of the NK-1 (Substance P) receptor with significant affinity for the L-type calcium channel as well. The latter property can be diminished by suitable substitution on the terminal nitrogen while maintaining good NK-1 receptor binding.
