Title of article
1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel
Author/Authors
Sander G. Mills، نويسنده , , Malcolm MacCoss، نويسنده , , Margaret A. Cascieri، نويسنده , , Sharon Sadowski، نويسنده , , Smita Patel، نويسنده , , Kerry L. Chapman، نويسنده , , Peter H. Hutson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
599
To page
604
Abstract
A series of 1,2,4-triacylpiperidines are shown to be potent antagonists of the NK-1 (Substance P) receptor with significant affinity for the L-type calcium channel as well. The latter property can be diminished by suitable substitution on the terminal nitrogen while maintaining good NK-1 receptor binding.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787382
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