Author/Authors :
Stephen J. Coval، نويسنده , , Michael A. Conover، نويسنده , , Ronald Mierzwa، نويسنده , , Arthur King، نويسنده , , Mohindar S. Puar، نويسنده , , David W. Phife، نويسنده , , Jin-Keon Pai، نويسنده , , Robert E. Burrier، نويسنده , , Ho-Sam Ahn، نويسنده , , George C. Boykow، نويسنده , , Mahesh Patel، نويسنده , , Shirley A. Pomponi، نويسنده ,
Abstract :
Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated from the marine sponge Xestospongia wiedenmayeri. Additional related marine natural products were also evaluated for CETP inhibition. Compounds that inhibit the activity of CETP may find utility as antiatherosclerosis therapy.
