Glycosylation of the active sequence ser-ile-lys-val-ala-val from the α1 chain of laminin reduces tumor cell attachment activity

N-terminal serine O-glycopeptides of SIKVAV-, a sequence located on the long arm of the α1 chain of laminin, were synthesized to study the effect of glycosylation on the adhesive properties of this biologically relevant peptide. The data show that covalently linked carbohydrates decrease the cell-attachment activity in a structurally dependent manner.