Author/Authors :
Vincent J. Kalish، نويسنده , , John H. Tatlock، نويسنده , , Jay F. Davies II، نويسنده , , Stephen W. Kaldor، نويسنده , , Bruce A. Dressman، نويسنده , , Siegfried Reich، نويسنده , , Mark Pino، نويسنده , , Dzuy Nyugen، نويسنده , , J Ernest Villafranca and Krzysztof Appelt، نويسنده , , Linda Musick، نويسنده , , Bor-wen Wu، نويسنده ,
Abstract :
The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorporated into the hydroxyethyl amine series to produce the potent antiviral compound (LY309391/ AG1310).
