Author/Authors :
Shripad S. Bhagwat، نويسنده , , Cynthia A. Fink، نويسنده , , Candido Gude، نويسنده , , Kenneth Chan، نويسنده , , Ying Qiao، نويسنده , , Yumi Sakane، نويسنده , , Carol Berry، نويسنده , , Raj D. Ghai، نويسنده ,
Abstract :
α-Mercaptoacyl dipeptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing carbon were preferred for optimal ACE inhibition while, R-stereochemistry was preferred for optimal NEP inhibition. Compounds containing alternative amino acid residues at the C-terminal position displayed optimal dual ACE/NEP inhibition when the stereochemistry was ‘S’ at this carbon atom.
