Title of article
4′-Substituted analogues of idoxifene: Antiestrogens and calmodulin antagonists
Author/Authors
Ian R. Hardcastle، نويسنده , , Martin G. Rowlands، نويسنده , , John Houghton، نويسنده , , Michael Jarman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
805
To page
808
Abstract
4′-substituted analogues of the antiestrogen idoxifene have been prepared. All the compounds were assayed for antagonism of calmodulin dependent c-AMP phosphodiesterase and for binding to rat uterine estrogen receptor. The 4′-amino compound was the most potent antiestrogen (RBA = 47) whilst retaining a similar calmodulin antagonism to idoxifene.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787419
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