Title of article
Nitrogen transfer in E. coli glucosamine-6P synthase. Investigations using substrate and bisubstrate analogs
Author/Authors
Marie-Ange Badet-Denisot، نويسنده , , Caroline Leriche، نويسنده , , Frédéric Massière، نويسنده , , Bernard Badet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
815
To page
820
Abstract
The compound 2-amino-2-deoxyglucitol-6P competitively inhibits E. coli glucosamine-6P synthase with respect to fructose-6P whereas glutamate γ-semialdehyde is a competitive inhibitor with respect to glutamine. These compounds, which exhibit good inhibitory properties (Km/Ki= 16 and 1000 respectively), were used in the synthesis of multisubstrate analogs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787421
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