Title of article :
Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
Author/Authors :
Kunitomo Adachi، نويسنده , , Toshiyuki Kohara، نويسنده , , Noriyoshi Nakao، نويسنده , , Masafumi Arita، نويسنده , , Kenji Chiba، نويسنده , , Tadashi Mishina، نويسنده , , Shigeo Sasaki، نويسنده , , Tetsuro Fujita، نويسنده ,
Abstract :
FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride), a novel synthetic immunosuppressant led by modification of ISP-I (myriocin, thermozymocidin) displayed potent immunosuppressive activity both in vitro and in vivo.
