Title of article
Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agents
Author/Authors
Yoichi Naka، نويسنده , , Ichimaro Yamada، نويسنده , , Hiroshi Ochi، نويسنده , , Mamoru Matsuura، نويسنده , , Yuko Nagamatsu، نويسنده , , Takanori Oe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
959
To page
962
Abstract
Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell binding affinity. 2-Methyl analogue (4b) was confirmed to be an optimal compound in this series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787450
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