Author/Authors :
Michael A. Eissenstat، نويسنده , , Gee-Hong Kuo، نويسنده , , John D. Weaver III، نويسنده , , Mark P. Wentland، نويسنده , , Ronald G. Robinson، نويسنده , , Kristina M. Klingbeil، نويسنده , , Deborah W. Danz، نويسنده , , Thomas H. Corbett، نويسنده , , Susan A. Coughlin، نويسنده ,
Abstract :
Replacement of the 3-carboxy group of quinolone topoisomerase II inhibitors by hydroxy substituted benzyl groups resulted in potent topoisomerase II inhibitors. The 2,6-dihydroxybenzyl analog, Win 64593, had a topo II EC50 of 96 nM and had potent in vitro cytotoxicity as well as murine antitumor activity.
