Title of article
Molecular design of novel PGI2 agonists without PG skeleton. II
Author/Authors
Nobuyuki Hamanaka، نويسنده , , Kanji Takahashi، نويسنده , , Yuuki Nagao، نويسنده , , Kazuhiko Torisu، نويسنده , , Hideo Takada، نويسنده , , Hidekado Tokumoto، نويسنده , , Kigen Kondo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1071
To page
1076
Abstract
Introduction of alkyl groups at the oximium carbon of the PGI2 agonists 3a and 4a has led to a series of potent PGI2 mimetics. The most effective compounds are 3c and 3d, whose agonistic activity for human platelet PGI2 receptors is almost the same as that of PGE1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787471
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