Author/Authors :
Nobuyuki Hamanaka، نويسنده , , Kanji Takahashi، نويسنده , , Yuuki Nagao، نويسنده , , Kazuhiko Torisu، نويسنده , , Hideo Takada، نويسنده , , Hidekado Tokumoto، نويسنده , , Kigen Kondo، نويسنده ,
Abstract :
Introduction of alkyl groups at the oximium carbon of the PGI2 agonists 3a and 4a has led to a series of potent PGI2 mimetics. The most effective compounds are 3c and 3d, whose agonistic activity for human platelet PGI2 receptors is almost the same as that of PGE1.
